Peter Krutzik
 
 
Author                                                                                                                              
 

picture.gif (17583 bytes)
Peter Krutzik

 

Peter Krutzik began to do research as a member of the Chamberlin Group because the project was a way of incorporating his two passions of chemistry and biology. Working on this project was exciting and challenging for Peter, giving him the "confidence to pursue a future career in research." He feels that his participation in research as an undergraduate has enhanced his educational experience by allowing him to apply the knowledge he has gained through his academic career. Peter advises students considering research to ask "one simple question…How much do you really want to learn? If the answer is `everything,' undergraduate research is the place to begin." triangle.gif (504 bytes)

next

 

Abstract                                                                                                                           
 

Due to their prevalence at brain synapses and their role in eliciting excitatory responses upon binding glutamate, glutamate receptors (GluRs) have recently become the focus of much neurological research. Of particular interest is the AMPA subclass of glutamate receptors present largely in the hippocampus, the putative memory center of the human brain. It has been found that by potentiating, or up-modulating, the response of AMPA receptors, learning and memory processes can be enhanced. In this study, various analogs of an AMPA desensitization-inhibiting compound, benzothiadiazine DP-60, were synthesized in an attempt to find a better drug candidate. Of the drugs synthesized, 2-hydroxyethyl-DP-60 (18b) and 2-acetonitrile-DP-60 (16) were found to be active inhibitors of desensitization. The various synthetic routes employed also expand current understanding of the reactivity of the benzothiadiazine ring. triangle.gif (504 bytes)

back.gif (221 bytes) next

 

Faculty Mentor                                                                                                                
 
facultypicture.gif (12811 bytes)

Richard Chamberlin

School of Physical Sciences

Peter Krutzik began his research in my laboratory working on a project designed to discover new compounds that might improve memory. For many older people, including some of us "absent minded professors," such a drug could make a significant difference in our daily lives. A key element in the search for any drug is stringing together entirely new molecules, as Peter has done on this project. A typical characteristic of this type of research, whether in an academic laboratory or at a large pharmaceutical company, is that it requires a joint effort between chemists and biologists working as a team. It is hard work, and no one knows what is just around the next corner. But that is part of the excitement, along with the possibility that something we dream up could truly improve the quality of life for many people.triangle.gif (504 bytes)

back.gif (221 bytes)





If you wish to view the paper in its entirety, please select the link given to the PDF file. pdf_logo.gif (126 bytes)[Peter Krutzik.pdf]


If you wish to download the Adobe Acrobat Reader,
please go to Adobe’s website (www.adobe.com).


Back to Journal 1999 Index

Copyright 1999 by the Regents of the University of California.  All rights reserved.