Kavita Singh

Kavita Singh.GIF (21312 bytes)
Kavita Singh

For Kavita Singh, maximizing her undergraduate college experience meant involving herself in biomedical research at UC Irvine.  During her second year, Kavita began her investigation of olfactory development.  The excitement of learning and fine-tuning lab and analytical skills was coupled with participating in dynamic research with findings that suggest a novel understanding of anterograde transport in the CNS.  Kavita plans to continue her commitment to research as a medical school student. triangle.gif (504 bytes)




During development, neurons compete for neurotrophic molecules from the targets they innervate and can degenerate without this support.  Although this retrograde mode of support is well-documented, recent evidence suggests that anterograde support is also important.  In the developing rat olfactory system, the olfactory nerve contacts the forebrain just before the olfactory bulbs form at embryonic day 13 to 14.  If contact between the nerve and forebrain does not occur, the bulbs do not develop, suggesting that anterograde trophic cues are supplied by the nerve.  Embryonic rat tissue was processed for in situ hybridization to localize mRNAs for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) along with their receptors, tyrosine kinase B (trkB) and C (trkC).  Neurotrophin-3 and BDNF mRNAs were found to be expressed in olfactory epithelium by embryonic day 14, at a time when mRNAs for trkB and trkC were also expressed in developing forebrain.   These findings suggest that olfactory bulb development may be influenced by neurotrophins anterogradely supplied by the olfactory nerve.triangle.gif (504 bytes)

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Faculty Mentor                                                                                                                
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Christine Gall

College of Medicine

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Kathleen Guthrie

College of Medicine

Charles Shivers set out to demonstrate that the conflict in Northern Ireland has not been due to religious differences, but to tensions between politically motivated interest groups.  He wanted to explain how the politics and economics of dominance have played a key role in perpetuating the conflict, and how this situation was changing, providing some hope for a breakthrough.  Not long after he finished his thesis the world watched in awe as the Good Friday Agreement was signed that brought peace to the long suffering region.  Charles persistently sharpened his thinking on the subject and revised the structure and style of his composition.  He can be congratulated for his insightful analysis and original writing.triangle.gif (504 bytes)

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Kavita Singh - TNeurotrophin Expression in the Developing Olfactory... [1] [2] [3] [4] [5] [6]

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